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An international research team led by Université de Montréal medical professor Christopher Rudd, director of research in immunology and cell therapy at Maisonneuve-Rosemont Hospital Research Centre, has identified a key new mechanism that regulates the ability of T-cells of the immune system to react against foreign antigens and cancer. T-cells orchestrate the response of the immune system. This work outlines how a receptor termed LFA-1 on the surface of T-cells mediates adhesion to other cells such as cancer cells. The work, published in Nature Communications, shows that LFA-1 mediates adhesion or de-adhesion by engaging a novel intracellular pathway in T-cells. International work over the past decade has underscored the importance of the manipulation of the immune system to combat cancers and infections. Manipulation of the new pathway outlined by Rudd and his co-researchers represents a new targeting strategy to promote immune-cell rejection of cancer.

See original article at: https://www.sciencedaily.com/releases/2017/07/170719084702.htm